Nimble is using its unique maskless chemical synthesis platform to synthesize and systematically discover novel medicines in a variety of therapeutic areas.

Nimble harnesses the power of photolithography and an extensive library of photoprotected amino acids to enable the design, synthesis, and screening of millions of diverse macrocycles at unprecedented speed.

Lead peptides are systematically engineered using the vast scale and chemical diversity of our amino acid library. Our catalog of photoprotected amino acids span both natural and non-natural amino acids including L-, D-, beta, gamma, and N-methyl monomers. We incorporate additional chemical reactions and orthogonal protecting groups to access unique molecular architectures . Nimble libraries are systematically designed using chemical matter that is either discovered or designed specifically with a target's profile in mind.

Accelerating Hit Discovery And Lead Optimization To Preclinical Phase

Nimble has designed a core technology that is powered by a massively parallel chemical synthesis platform. We’ve paired this with a variety of molecule enhancing assay capabilities and robust chemo-informatics to enable rapid discovery and optimization of peptidic compounds with optimal drug-like properties.

Offering Intelligent Libraries With Limitless Possibilities

Our synthesis platform enables intelligent library designs containing millions of peptidic molecules. Our custom amino acid library contains over 350 different amino acids (L-, D-, beta, gamma, non-natural, cyclic backbone modifiers, linkers, etc.) including access to thousands of N-alkyl variants and carboxylic acid capping possibilities. This diverse amino acid catalog coupled with the incorporation of orthogonal protection chemistry enables the systematic discovery of novel linear, macrocyclic and branched molecules.

Integrating Drug Like Properties Into Discovery & Optimization Campaigns

We’ve developed highly parallelized assays that help precisely and efficiently navigate a massive chemical space through rapid structure–activity relationship (SAR) analysis paired with molecule enhancing assays designed to incorporate optimal drug-like properties in the earliest stage of hit discovery to lead optimization.

Proven To Systematically Unlock Novel Chemical Matter

Nimble’s core capabilities have been applied in various studies and have helped unlock new learnings and discoveries.


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